河南医科大学学报2001，Vol.36Issue(3)：303-305,3.
卵巢上皮性癌组织中细胞周期蛋白D1与p16的表达
Expression of CyclinD1 and p16 in human ovarian epithelial cancer
摘要
Abstract
Aim：To explore the role of expression of CyclinD1 and p16 in the progression of ovarian cancer.Methods： Immunohistochemical staining technique was used to examine the expression of CyclinD1 and p16 in 40 cases of ovarian epithelial cancers, 12 cases of benign ovarian tumors and 10 cases of normal ovaries. Both expressions were analyzed in terms of their relationships to clinical stages,differentiated grades,histological types,lymphatic node metastasis of the disease and the survival time of the patients.Results:①The higher expressions of CyclinD1 were found in groups at poorly clinical stage,with lymphatic node metastasis and short survival time than that of groups in well clinical stage,non-lymphatic node metastasis and long survival time (P＜0.05);It was higher in group of low differentiated grade than that of high differentiated grade.The expression was apparently different while grade Ⅲ was compared with grade Ⅱ or grade Ⅰ(P＜0.05).②The majority at well clinical stage orhigh differentiated grade,or with non-lymphatic node metastasis and long survival time were positive for p16 while it was negative in most of the poorly clinical stage,low differentiated grade,lymphatic node metastasis and short survival time (P＜0.05).③)There was negative correlation between the expression of p16 and the expression of CyclinD1.Conclusion： The low expression of p16 and the high expression of CyclinD1 are closely correlated to the clinicopathological parameters of ovarian cancer and have synergism effect in progression of ovaian epithelial cancer.关键词
卵巢上皮性瘤/细胞周期蛋白D1/p16分类
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赵先兰,乔玉环,史惠蓉,李留霞..卵巢上皮性癌组织中细胞周期蛋白D1与p16的表达[J].河南医科大学学报,2001,36(3):303-305,3.
