中国临床康复2003，Vol.7Issue(22)：3038-3039,2.
动脉粥样硬化性脑梗死与低密度脂蛋白亚组分颗粒大小关系的研究
Association of small low density lipoprotein particles with the incidence of the patients of the atherosclerosic cerebral infarction
谷月宇 1郭阳 2李强 2韩顺昌2
作者信息
- 1. 鞍山市中心医院康复科,辽宁省鞍山市,114001
- 2. 中国医科大学附属第二医院,辽宁省沈阳市,110003
- 折叠
摘要
Abstract
AIM: To study the correlation of the diameter of small LDL particles with the incidence of atherosclerosic cerebral infarction( ACI) . METHODS: The LDL plasmas were obtained by using density ladder supercentryfugation method in 32 ACI patients and another 32 healthy persons in the control group.The diameter, distribution and electrophoresis areas graphs of the LDL particles were analyzed by using 2.5%- 16.0% non denaturing polyacylamide gradient gels electrophresised method. RESULTS: ① The levels of TG,TC,LDL C, and Apo B in ACI group were significantly high (t=4.03－ 8.37,P< 0.01).② The mean diameter of LDL particles in ACI group[(24.8± 0.7)nm] were more smaller than the mean diameter in the control group [(26.0± 0.6)nm,t=4.78,P< 0.01];the distribution of A and B pattern subfraction between the two groups was different, the distribution of B pattern LDL subfraction in ACI group was more significantly high than that in the control group.(t=6.80,P< 0.05).③ The relative percentage of small and density LDL particles in the ACI group(50± 10)％ increased more significantly than that in the control group (t=7.76,P< 0.001). ④ There were negatively correlations between the diameter of LDL subfraction in ACI group with TG(r=－ 0.47,P< 0.01),TC(r=－ 0.51,P< 0.01),LDL C(r=－ 0.36, P< 0.05)and Apo B (r=－ 0.46, P< 0.05). CONCLUSION: The dominant LDL subfractions in ACI group were the small and density B pattern LDL that had a closely correlation with the incidence of ACI.It might be one of the dangerous factors of ACI.There was negative correlation between B pattern LDL with the levels of TG that adjusted the diameter and formulation of LDL subfractions. 关键词
脂蛋白类,LDL/动脉粥样硬化/脑梗塞分类
医药卫生引用本文复制引用
谷月宇,郭阳,李强,韩顺昌..动脉粥样硬化性脑梗死与低密度脂蛋白亚组分颗粒大小关系的研究[J].中国临床康复,2003,7(22):3038-3039,2.
