中华医学杂志（英文版）2003，Vol.116Issue(2)：309-311,3.
Tibetan patients with essential hypertension caused by underlying oxidative meta bolism dysfunction and depressed nitric oxide synthesis
Tibetan patients with essential hypertension caused by underlying oxidative meta bolism dysfunction and depressed nitric oxide synthesis
李党生 1王雄伟 2符中明 2余军 2达文莉 2彭顺舟 2王先贵2
作者信息
- 1. The Third Department of Internal Medicine, The 476th Hospital of PLA, Fuzhou 350002, China
- 2. The 41st Hospital of PLA, Shannan in Tibet 856100, China
- 折叠
摘要
Abstract
Objective To assess the role of oxidative metabolism and nitric oxide synthesis for elucid ating their pathophysiological mechanisms in a Tibetan patient with essential hyp ertension. Methods The serum levels of total superoxide dismutase (T-SOD), malondialdehyde (MDA), total antioxidant capacity (T-AOC), nitric oxide (NO) and nitric oxide synthase (NOS) were assayed in sixty native Tibetans (thirty hypertensive patients and t hirty healthy volunteers as control). Results The levels of T-SOD, T-AOC, NO and NOS were significantly lower in the patient group than in the control group (P<0.01); MDA was significantly higher in the patient group than in the control group (P<0.01). The level of MDA ha d a strong negative correlation with T-SOD, T-AOC, NO and NOS (r=-0.82, -0.76, -0.79, -0.73, respectively, P<0.001 for all). Conclusion Tibetan patients with essential hypertension (EH) may have underlying oxidative metabolism dysfunction and depressed NO synthesis, both responsible for the hype rtensive process.关键词
Tibetan patient/essential hypertension/pathogenesis/oxidative metabolism/nitric oxide synthesisKey words
Tibetan patient/essential hypertension/pathogenesis/oxidative metabolism/nitric oxide synthesis分类
医药卫生引用本文复制引用
李党生,王雄伟,符中明,余军,达文莉,彭顺舟,王先贵..Tibetan patients with essential hypertension caused by underlying oxidative meta bolism dysfunction and depressed nitric oxide synthesis[J].中华医学杂志（英文版）,2003,116(2):309-311,3.
