中德临床肿瘤学杂志（英文版）2008，Vol.7Issue(6)：311-314,4.
吉西他滨与三维适形放疗同步治疗局部晚期非小细胞肺癌的临床观察
Clinical observation of gemcitabine and concomitant three-dimensional conformal radiotherapy in the treatment of locally advanced non-small cell lung cancer
Jing Cheng 1Gang Wu 1Hongge Wu 1Jun Xue1
作者信息
- 1. Department of Oncology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430023,China
- 折叠
摘要
Abstract
Objective:To evaluate lhe clinical effect of gemcitabine and concurrent three-dimensional conformal radiation therapy(3D-CRT)for locally advanced non-small cell lung cancer(NSCLC).Methods:From April 2002 to June 2005,38 patients with inoperable stage Ⅲ NSCLC were treated with gemcitabine and 3D-CRT simultaneously.Chemotherapy consisted of intravenously gemcitabine 350 mg/m2 on days 1,8,15,22,29,36.3D-CRT was delivered up to a total dose of 60-64 Gy with a 2.0 Gy dose fraction per day,5 days per week.Results:The overall response rates of primary tumor and mediastinum metastatic node were 86.8%(33/38)and 90.6%(29/32)respectively,and 91.7%(22/24)and 78.6%(11/14)for squamous cell carcinoma and adenocarcinoma respectively.The acute side effects of patients were mostly myelosuppression,nausea,vomiting,radiation-induced esophagitis and pneumonitis(RTOG Ⅰ/Ⅱ),however,all of them were cured.Conclusion:Concurrent application of gemcitabine and 3D-CRT can improve the overall response rate for locally advanced NSCLC without aggravating the side effects.关键词
non-small cell lung cancer/three-dimensional conformal radiation therapy/chemotherapy/concurrent chemo radiotherapy/gemcitabineKey words
non-small cell lung cancer/three-dimensional conformal radiation therapy/chemotherapy/concurrent chemo radiotherapy/gemcitabine分类
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Jing Cheng,Gang Wu,Hongge Wu,Jun Xue..吉西他滨与三维适形放疗同步治疗局部晚期非小细胞肺癌的临床观察[J].中德临床肿瘤学杂志（英文版）,2008,7(6):311-314,4.
