中国中西医结合杂志2001，Vol.21Issue(1)：31-33,3.
葛根素对不稳定心绞痛患者血小板颗粒膜蛋白、溶酶体膜蛋白及血浆纤溶酶原激活物抑制物、C-反应蛋白的影响
Effect of Puerarin on Platelet Activating Factors CD63 and CD62P, Plasminogen Activator Inhibitor and C-reactive Protein in Patients with Unstable Angina Pectoris
罗助荣 1郑冰2
作者信息
- 1. 解放军福州总医院心脏内科 福州 350025
- 2. 福建中医学院附属第二人民医院检验科
- 折叠
摘要
Abstract
Objective: To explore the action of platelet surface activityprotein (platelet granule membrane protein CD63 and lysosome membrane protein CD62P), plasminogen activator inhibitor (PAI-1) and C-reactive protein (C-RP) in occurrence and development of unstable angina pectoris (UAP), and the effect of Puerarin on them. Methods: Patients with UAP were randomly divided into the treated group (32 cases, treated with Puerarin) and the control group (27 cases, treated with Ticlid), the therapeutic course was 4 weeks for both groups. Changes of CD63, CD62P, PAI-1 and C-RP before and after treatment were observed. Results: The levels of CD63, CD62P, PAI-1 and C-RP were higher in UAP patients than those in normal subjects and in the patients with stable angina pectoris (P＜0.05 or P＜0.01). These parameters were increased along with the aggravating of patients in Braunwald′s degree. After 4-week treatment, the above-mentioned parameters lowered in both groups (P＜0.05 or P＜0.01), and comparison between the two groups showed no significant difference statistically. Conclusion: Platelet activation, plasminogen activator and C-RP play important roles in the occurrence and development of UAP. The obvious effect of Puerarin in anti-platelet activation, improving plasminogen activator and relieving inflammatory reaction was of great importance in preventing the occurrence and development of acute coronary syndrome clinically.关键词
不稳定心绞痛/葛根素/血小板活化/纤溶/炎症反应分类
医药卫生引用本文复制引用
罗助荣,郑冰..葛根素对不稳定心绞痛患者血小板颗粒膜蛋白、溶酶体膜蛋白及血浆纤溶酶原激活物抑制物、C-反应蛋白的影响[J].中国中西医结合杂志,2001,21(1):31-33,3.
