军事医学科学院院刊2001，Vol.25Issue(1)：31-33,38,4.
本芴醇对疟原虫DNA含量及溶酶体pH值的影响
Effect of benflumetol on DNA content and pH value of the lysosome of Plasmodium berghei
摘要
Abstract
Objective:To study the antimalarial mechanism of benflumetol (B). Methods: Flow cytometry (FCM) was used to analyze the effects of B and chloroquine (CQ) on DNA content of Plasmodium berghei and pH value of the lysosome of malarial parasites. Results: DNA content of the plasmodia not treated with any drugs was not changed in 24 hours,while benflumetol could decrease the DNA content: the DNA content began to decrease 2 h after the drug administration and reached the minimum by 16 h, but somewhat increased at 24 h after administration. The pH in the lysosome increased 1 h and restored premedication level 4 h after benflumetol administration. Chloroquine had the same effects on DNA and lysosome pH of malarial parasites.Conclusions: The antimalarial mechanism of benflumetol is directly related to its effect to inhibit the synthesis of DNA.关键词
本芴醇/疟原虫,伯氏/溶酶体/DNA含量/流式细胞术分类
医药卫生引用本文复制引用
苏瑞斌,时云林,李国福,赵京花..本芴醇对疟原虫DNA含量及溶酶体pH值的影响[J].军事医学科学院院刊,2001,25(1):31-33,38,4.
