中国药理学与毒理学杂志2001，Vol.15Issue(1)：31-34,4.
镍对豚鼠心室肌收缩活动及慢反应电位的影响
Effects of Ni2+ on contractions and slow action potentials in guinea pig ventricular myocardium
刘北英 1钮伟真 1曹敬清 1韩大英1
作者信息
- 1. 首都医科大学心血管研究室, 北京 100054
- 折叠
摘要
Abstract
The effects of Ni2+ on contractions and slow action potentialswere studied by using micro-force transducer and microelectrode methods in vitro in guinea pig ventricular myocardium. The results showed：① 0.05 mmol.L-1 NiCl2 produced a positive chronotropic effect，but in the high concentrations (0.1－1.0 mmol.L-1)，Ni2+ produced a dose-dependent negative chronotropic effect. ②NiCl2 0.5 mmol.L-1 inhibited post-rest potentiation and positive staircase phenomena(PSP), but didn′t reverse PSP. ③NiCl2 0.1－1.0 mmol.L-1 reduced max and amplitude of slow action potentials. ④In high concentrations (>0.5 mmol.L-1)，the effects of Ni2+ were strong and lasted long，and were more significant in active preparations．These results suggest that Ni2+ inhibit myocardial contraction by many ways as Ca2+ antagonist, and from the event that low concentration of Ni2+ potentiated myocardial contraction, there be different mechanisms of its effects on myocardial contraction.关键词
镍/心肌收缩/动作电位分类
生物科学引用本文复制引用
刘北英,钮伟真,曹敬清,韩大英..镍对豚鼠心室肌收缩活动及慢反应电位的影响[J].中国药理学与毒理学杂志,2001,15(1):31-34,4.
