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Preparation and characterization of chitosan/nano-hydroxyapatite composite used as bone substitute materials

Zhang Li Li Yubao Zhou Gang Wu Lan Mu Yuanhua Yang Zheng

高技术通讯(英文版)2007,Vol.13Issue(1):31-35,5.
高技术通讯(英文版)2007,Vol.13Issue(1):31-35,5.

Preparation and characterization of chitosan/nano-hydroxyapatite composite used as bone substitute materials

Preparation and characterization of chitosan/nano-hydroxyapatite composite used as bone substitute materials

Zhang Li 1Li Yubao 1Zhou Gang 1Wu Lan 1Mu Yuanhua 1Yang Zheng1

作者信息

  • 1. Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, P.R.China
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摘要

Abstract

Chitosan/nano-hydroxyapatite composites with different weight ratios were prepared through a co-precipitation method using Ca(OH)2, H3PO4 and chitosan as starting materials. The properties of these composites were characterized by means of TEM, IR, XRD, TGA, bum-out tests and universal matertial testing machine. The results showed that the HA synthesized here was poorly crystalline carbonated nanometer crystals and dispersed uniformly in chitosan phase and there was no phase-separation between the two phases. The addition of n-HA resulted in a decrease of decomposing temperature of chitosan. Because of the interactions between chitosan and n-HA, the mechanical properties of these composites were improved, and the maximum value of the compressive strength was measured to be about 120MPa corresponding to the chitosan/n-HA composite with a weight ratio of 30/70.

关键词

chitosan/nano-hydroxyapatite/composite/co-precipitation

Key words

chitosan/nano-hydroxyapatite/composite/co-precipitation

分类

医药卫生

引用本文复制引用

Zhang Li,Li Yubao,Zhou Gang,Wu Lan,Mu Yuanhua,Yang Zheng..Preparation and characterization of chitosan/nano-hydroxyapatite composite used as bone substitute materials[J].高技术通讯(英文版),2007,13(1):31-35,5.

基金项目

Supported hy the China 973 Funds(China-Netherlands Co-project)(2004CB720604). (China-Netherlands Co-project)

高技术通讯(英文版)

OAEI

1006-6748

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