摘要
Abstract
Aim To evaluate the changes of the arterial function in essential hypertensive (EH) patients with metabolic syndrome (MS). Methods 64 patients with EH were assigned into two groups: EH with MS group (n=32), EH without MS group (n=32). 31 healthy subjects were served as normal control. Brachial-ankle pulse wave ve-locity(BaPWV) was measured using an automatic device (VP1000), arterial elastic index (C1-large artery and C2-small artery) were measured by the CVProfiler-2020 pulse wave analysis instrument. Results BaPWV in EH with MS group (1 916.5±318.0 cm/s) and EH without MS group (1 757.6±313.9 cm/s) were higher than that in control group (1 517.9±315.0 cm/s, P<0.01 and <0.05); and BaPWV in EH with MS group was higher than that in EH without MS group (P<0.05). The magnitude of C1 and C2 reduced in proper order in control group, EH without MS group, EH with MS group (C1:113.2±46.2, 91.1±35.0 and 66.6±31.1 mL/mmHg, P < 0.01; C2:505±244, 355±195 and 253±116 mL/mm Hg, P<0.05). Pearson correlation showed that BaPWV was positively related with age, systolic blood pressure, pulse pressure difference and triglyceride (P<0.01), negatively related with high density lipoprotein cholesterol (HDLC) (P<0.01); C1 and C2 were positively related with HDLC (P<0.05 and 0.01), and negatively related with age, systolic blood pressure,pulse pressure difference and triglyceride (P<0.01). Conclusion MS may aggravate the dysfunction of artery in EH patients.关键词
高血压病/代谢综合征/肱-踝脉搏波传导速度/动脉弹性Key words
Metabolic Syndrome/ Essential Hypertension/ Brachial-Ankle Pulse Wave Velocity/ Arterial E-lasticity分类
医药卫生
