摘要
Abstract
BACKGROUND: Diazepam can cause short term memory defect of patients,especially to aged people, it can impair cognitive function and may not aid sleep when taken continuously for years. Piractam can sitmulate learning and memory by multiple mechanism. At present, there are few reports about the therapeutic effects and side effects when using these two medicines together.OBJECTIVE: To discuss the impact of combined application of piracetam and diazepam on the side effect of diazepam on hypomnesia and the therapeutic reaction of sedation and hyponosis.DESIGN: Completely randomized design.SETTING and PARTICIPANTS: The experiment was done in the pharmacology teaching section of Wenzhou Medical College. The necessary materials include 415rats of Kunming species, diazepam, piracetam, glutamicacid(Glu)and γ-aminiobutyricacid (GABA).METHODS: In dark aviodance test and the spontaneous activities, rats were divided into normal saline group, diazepam group, piracetam group, and piracetam + diazepam group. In the Y-maze test, there were normal saline group, Glu group, GABA group, GABA + Glu group, diazepam + Glu group,piracetam + GABA group, diazepam group and diazepam + piracetam group. The times og mistakes of mistates and latent period recorded during lesrning and testing. And then observed their spontaneous activities and learning ability of distinguishing space.MAIN OUTCOME MEASURES: The frequency of mistakes made by rats during learning and tests. Spontaneous activity and learning ability of distinguishing space.RESULTS: Diazepam obviously impairs the abilities of memory acquiring and learning how to distinguish open space of rats. But the use of piracetam improve clesrly these damages while the central inhibitive effects of diazepam were not affected by piracetam.CONCLUSION: Piracetam can redress the amnesia caused by diazepam without its central inhibitive effects affected.关键词
吡拉西坦/谷氨酸/记忆/学习分类
医药卫生
