中国现代医学杂志2005，Vol.15Issue(21)：3208-3211,3218,5.
促红细胞生成素对缺血海马CA1区神经元Bcl-xl和细胞色素C作用的相关性研究
Effect of erythropoietin pretreatment on relative expression of bcl-xl and CytC in hippocampal CA1 subregion after transient global cerebral ischemia
孟宪栋 1罗晓红 1陈俊抛 2葛江聪 1张新宇1
作者信息
- 1. 兰州军区总医院,干部病房,甘肃,兰州,730050
- 2. 珠江医院,神经内科,广东,广州,510280
- 折叠
摘要
Abstract
[ Objective ] To explore the neuroprotection mechanism of erythropoietin (EPO). [Methods ] Transient global cerebral ischemia model was made by 4-VO technique. Male SPraque-Dawley rats were as the experimental objects, which were randomly separated into 3 of groups including Sham, Saline control and EPO-Pretreatment. At 3hours before global cerebral ischemia, saline or EPO was respectively injected into the lateral ventricle of rat, with help of stereotaxic coordinates, upon the designed conditions. The Sham rats were only performed the incision on cervix but without any treatment on the arteries. Observed if expression of cytochrome c (CytC) was related to bcl-xl at 24 hours after the model operation, in hippocampal CA1 subregion. [Results] Expression of CytC was not related to bcl-xl in Sham and Saline control group, but was evidently related to bcl-xl in EPO-Pretreatment(r = 0.818;P =0.013). [Conclusions] Pretreatment of EPO could inhibit CytC releasing into cytoplasm in hippocampal CA1 subregion in the modeled rat, which could relate to promoted expression of bcl-xl.关键词
促红细胞生成素/脑缺血/Bcl-xl/细胞色素CKey words
erythropoietin/brain ischemia/Bcl-xl/CytC分类
医药卫生引用本文复制引用
孟宪栋,罗晓红,陈俊抛,葛江聪,张新宇..促红细胞生成素对缺血海马CA1区神经元Bcl-xl和细胞色素C作用的相关性研究[J].中国现代医学杂志,2005,15(21):3208-3211,3218,5.
