南京医科大学学报（英文版）2007，Vol.21Issue(5)：321-323,3.
Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis
Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis
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作者信息
- 1. Department of orthopedics, Shengli Oil-field Central Hospital, Dongying 257034, Shandong province, China;Department of orthopedics, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei province, China;Department of orthopedics, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei province, China
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摘要
Abstract
Objective:To investigate the gene expression of osteoprotegerin(OPG) and osteoclast differentiation factor(ODF) in the bone tissue of patients with hip fracture due to osteoporosis. Methods:OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers(over 50 years old) with hip fracture(Observer Group) and 30 cases of hip facture sufferers with no osteoporosis(Control group) were analyzed with the Semi-Quantitative RT-PCR method. Results:The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion:Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.关键词
osteoporosis/ fracture/ osteoprotegerin/ osteoclast differentiation factorKey words
osteoporosis/ fracture/ osteoprotegerin/ osteoclast differentiation factor分类
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..Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis[J].南京医科大学学报（英文版）,2007,21(5):321-323,3.
