中国现代医学杂志2001，Vol.11Issue(3)：32-33,2.
缺氧模型用于扩管药耳蜗效应评定的研究
A HYPOXIA MODEL FOR EVALUATING THE COCHLEAR EFFECT OF VASODILATOR
摘要
Abstract
Objective: To explore the possibility to evaluate the cochlear effect of vasodilator by the hypoxia model. Methods:theeffects of salvia mitiorribizae,ligustrazine and papaverine which had been testified to be improve the cochlear microcirculation on theABR were be o bserved in the guinea pig hypoxic modd(7％O2 or 5％O2). Results: Conpared with the control group, after animalswere subjected to hypoxia of 7％ oxygen for 30 minutes,the cochlear effect of three vasodilators were be confirmed by the marked reduce of the ABR threshold shift,the latency and the amplitude of wave I didn't appear and differen~ among groups. after ventilatedwith hypoxic gas of 5％ oxygen for 30 minute,only the salvia mitiorribizae and the papaverine's cochlear effect were be verified. Conclusion: the model of cochlear electrophysiology during hypoxia could be utilized to evaluate the cochlear effect of vasodilator, the appropriate hypoxia gas is 7％ oxygen,the threshold shift of ABR could be used as indexes.关键词
低氧/听性脑干反应/扩管药分类
医药卫生引用本文复制引用
柯朝阳,吴展元,张志坚,肖伯奎..缺氧模型用于扩管药耳蜗效应评定的研究[J].中国现代医学杂志,2001,11(3):32-33,2.
