中德临床肿瘤学杂志（英文版）2009，Vol.8Issue(6)：326-328,3.DOI:10.1007/s10330-009-0056-0
胰岛素样生长因子-1在乳腺癌组织中的表达
Expression of insulin-like growth factor-1 in breast cancer tissues
Mingxun Chen 1Mengquan Li 1Jingruo Li1
作者信息
- 1. Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
- 折叠
摘要
Abstract
Objective: We investigated the expression of insulin-like growth factor-1 (IGF-1) so as to explore its relationship with carcinogenesis and development of breast cancer. Methods: IGF-1 mRNA levels in tissues of breast cancer, adjacent breast cancer in 70 cases breast cancer patients were analyzed by RT-PCR with the normal breast tissues of paired breast as the control. Results: The level of IGF-1 mRNA expression in breast cancer tissues was significantly higher than that in the paired adjacent to breast cancer tissues, normal mammary gland tissues. The ration of IGF-1/β-actin were 0.679±0.075, 0.463±0.085, 0.305±0.031, respectively. There was significant difference between different groups (P < 0.005). Expression of IGF-1 was associated with lymph node metastasis, pathological staging and estrogen receptor status of breast cancer and no significant relationship with tumor pathological grouping (P >0.005). Conclusion: The high-level expression of IGF-1 in breast cancer tissues is correlated with carcinogenesis, development and metastasis of breast cancer.关键词
insulin-like growth factor-1 (IGF-1)/breast cancerKey words
insulin-like growth factor-1 (IGF-1)/breast cancer分类
医药卫生引用本文复制引用
Mingxun Chen,Mengquan Li,Jingruo Li..胰岛素样生长因子-1在乳腺癌组织中的表达[J].中德临床肿瘤学杂志（英文版）,2009,8(6):326-328,3.
