中国中西医结合杂志2001，Vol.21Issue(5)：328-331,4.
双黄升白冲剂对化疗引起骨髓抑制的临床研究及小鼠骨髓超微结构的观察
Clinical and Experimental Study on Effect of Shuanghuang Shengbai Granule on Myelosuppression Induced by Chemotherapy and Ultrastructure Observation of Bone Marrow in Mice
摘要
Abstract
Objective: To observe the leukocyte increasing effects ofShuanghuang Shengbai Granule (SHSBG) in tumor patients treated by chemotherapy (CT) and its function on bone marrow hematopoietic microenvironment in mice. Methods: Patients of non-small-cell lung cancer and breast, gastric or intestinal cancer, who were retreated with CT, were enrolled and divided into 4 groups randomly. The 28 cases in the treated group 1 received SHSBG and CT simultaneously. The 27 cases in the treated group 2 also received firstly CT, and SHSBG started when WBC count lowered to less than 4×109／L after CT. The control group 1 and 2 (n＝33 and n＝24) was treated by the method similar to that applied to the treated group 1 and 2 respectively but with Rubidate instead of SHSBG. Experimental study of observing bone marrow ultrastructure in mice was also conducted with electron microscopy. Results: The total leukocyte increasing effective rate occurred in the treated group 1 was 75.00%, that in the treated group 2 was 88.89%, in the control group 1 was 54.55% and in the control group 2 was 58.33%. There was significant difference between the treated groups and the control groups (P＜0.01). Experimental study showed that SHSBG has good bone marrow hematopoietic microenvironment protecting and improving effect in mice. Conclusion: SHSBG has obvious protecting and treating effect on CT caused bone marrow suppression in tumor patients.关键词
双黄升白冲剂/化疗骨髓抑制/升白细胞/骨髓微环境分类
医药卫生引用本文复制引用
徐振晔,朱晏伟,周卫东,张晖,鞠艳芳,赵丽红,邓海滨,吴继,沈德义,张蕙心..双黄升白冲剂对化疗引起骨髓抑制的临床研究及小鼠骨髓超微结构的观察[J].中国中西医结合杂志,2001,21(5):328-331,4.基金项目
上海市科委科研基金资助课题(No.964019037) （No.964019037）
