河南医科大学学报2000，Vol.35Issue(4)：331-333,3.
罗红霉素颗粒剂在健康人体内的相对生物利用度
Relative bioavailability of roxithromycin granule in healthy volunteers
张莉蓉 1乔海灵 1贾琳静 1张启堂 1刘凤芝 1朱振峰 1马统勋1
作者信息
- 1. 河南医科大学临床药理学教研室 郑州 450052
- 折叠
摘要
Abstract
Aim: To study the relative bioavailability of roxithromycin granule. Methods: The roxdthromycin concentrationsin serum were determined by microbiological method after a single oral dose of roxithromycin granule and roxithromycin tablet wererespectively given to 8 volunteers in an open randomized cross-over test. Results: The concentration-time curves of roxithromycingranule and tablet fitted to a two-compartment open model. The Cmax was ( 11. 40 ± 1.60 ) mg· L- 1 and ( 9.65 ± 1.26) mg· L- 1;Tmax was (1.36±0.24) h and (1.71 ±0.27) h; T1/2 was (12.88±0.88) h and (13.46±0.95) h;AUC was (111.18± 18.44)mg·h·L-1 and (108.91 ± 16.94) mg·h·L- 1,of roxithromycin granule and roxithromaycin tablet respectively. The pharmacokineticparameters obtained from our studies showed no significant difference between two formulations ( P > 0.05). The relative bioavail-ability was ( 102.08 ± 8.02 ) % (88.01% ～ 115.53 % ) of roxithromycin granule. Conclusion: The results of statistical analysis suggest that the two fonnulations be bioequivalent.关键词
罗红霉素/药物动力学/生物利用度Key words
roxithromycin/pharmacokinetics/bioavailability分类
医药卫生引用本文复制引用
张莉蓉,乔海灵,贾琳静,张启堂,刘凤芝,朱振峰,马统勋..罗红霉素颗粒剂在健康人体内的相对生物利用度[J].河南医科大学学报,2000,35(4):331-333,3.
