山东中医药大学学报2009，Vol.33Issue(4)：332-334,3.
调肝脾方与补肝肾方对佐剂大鼠红细胞免疫和细胞因子影响的比较研究
Comparative study on adjusting liver and spleen prescription and tonifying liver and kidney prescription on erythrocyte immune and cytokines of adjuvant rats
摘要
Abstract
Objective: To explore adjusting liver and spleen prescription and tonifying liver and kidney prescription on erythrocyte immune and cytokines of adjuvant rats by observing the serum cytokines interleukin-4(IL-4),interfer-on-γ(IFN-γ) and the ratio and erythrocyte immune function. Methods: According to body weight,Wistar rats were randomly divided into normal group,model group,adjusting liver and spleen prescription group,tonifying liver and kidney pre-scription group,torch-gen-chip group,fenbid group. The autoimmune arthritis rats were induced by proinflammatory adjuvant method. The serum IL-4,IFN-γ were detected by ELISA method,and erythrocyte immune function were test-ed by RBC-C3b rosette and its receptors. Results: The serum IFN-γ/IL-4 ratio of the model group was significantly increasod(P<0.01). RBC-C3b rosette receptor rate was significantly lower(P<0.01),RBC-IC rosette rate significantly increased(P<0.01). Each treating group could significantly improve these indexes,and the adjusting liver and spleen prescription group had the best effection to recover the ratio of IFN-γ/IL-4 to resume and to lower RBC-IC rosette rate. Conclusion: Adjusting liver and spleen prescription has significent effects on regulating cytokines and clearing away the harmful immune complexes of adjuvant rats.关键词
调肝脾方/补肝肾方/细胞因子/红细胞免疫/大鼠/实验研究Key words
adjusting liver and spleen prescription/tonifying the liver and kidney prescription/cytokines/erythrocyteimmune/rat/experimental study分类
医药卫生引用本文复制引用
虞靖彬,叶蕾,秦林,彭欣..调肝脾方与补肝肾方对佐剂大鼠红细胞免疫和细胞因子影响的比较研究[J].山东中医药大学学报,2009,33(4):332-334,3.基金项目
国家自然科学基金资助课题(编号:39670868),山东省自然科学基金资助课题(编号:Y2001C18) （编号:39670868）
