中国临床康复2003，Vol.7Issue(2)：334-335,2.
刺激迷走神经后不同组织肿瘤坏死因子变化的实验研究
Experiment studies of tumor necrosis factor changes in different tissues after stimulating vagus nerve
摘要
Abstract
AIM:To investigate the effect of proinflammatory cytokine and anti inflammatation cytokine on liver and lung tissues in rats with endotoxemia.METHODS:Male Wistar rats were randomly divided into 4 groups: group treated with stimulating vagus nerve, group receiving lipopolysaccharide(LPS) intravenous injection after transecting vagus nerve, group treated with sham operation and group treated with injecting LPS intravenously alone, and then measured the levels of TNF α in liver and lung and those of cortisol and Alanine aminotransferase (ALT) in plasma.RESULTS:Compared with group treated with sham operation,LPS treated groups showed a significant increase in TNF level, which was at most 15 fold higher than that of the former group.There was a significant decrease in TNF level in group treated with stimulating vagus nerve,compared with both group receiving LPS intravenous injection after transecting vagous nerve and group treated only with LPS.In addition,we observed plasma cortisol level in LPS treated group was much higher than other 3 groups and the plasma ALT level was greatly lower than that of group treated only with LPS.CONCLUSION:Stimulating vagous nerve can significantly decrease the production of proinflammatory cytokine and alleviate inflammation in rats with endotoxemia.关键词
vagus nerve/electrical stimulation/tumor necrosis factor α/cortisolKey words
vagus nerve/electrical stimulation/tumor necrosis factor α/cortisol分类
医药卫生引用本文复制引用
姜小国,胡森,石德光,孙丹,晋桦,黎君友,柳琪林..刺激迷走神经后不同组织肿瘤坏死因子变化的实验研究[J].中国临床康复,2003,7(2):334-335,2.基金项目
Supported by the National Military Medical Science Fundation of the Tenth Five year Plan.(No.01L081) （No.01L081）
