动物学研究2008，Vol.29Issue(3)：335-345,11.
基于RCAS-TVA技术的哺乳动物模型
Mammalian Models Based on RCAS-TVA Technique
摘要
Abstract
The retroviral vector (RCAS) has been widely used in avian system to study development and diseases, but is not suitable for mammals which do not produce the retrovirus receptor TVA. In this review, we trace the current uses of RCAS-TVA approach in mammalian system with improved strategies, including generation of tv-a transgenic mice, use of soluble TVA receptor and retroviral receptor-ligand fusion proteins, improvement of RCAS vectors, and compare a series of mammalian models in variant studies of gene function, development, oncogenesis and gene therapy. All those studies demonstrate that the RCAS-TVA based mammalian models are powerful tools for understanding the mechanisms and target treating of human diseases.关键词
RCAS载体/TVA/特异性启动子/转基因动物/哺乳动物模型Key words
RCAS vector/ TVA/ Specific promoter/ Transgenic animal/ Mammalian model分类
生物科学引用本文复制引用
牛屹东,梁蜀龙..基于RCAS-TVA技术的哺乳动物模型[J].动物学研究,2008,29(3):335-345,11.基金项目
北京大学人民医院研究与发展基金(RDB2007-03)Supported by Peking University People's Hospital Research and Development Foundation (RDB2007-03) （RDB2007-03）
