中国现代医学杂志2005，Vol.15Issue(22)：3361-3365,5.
基质金属蛋白酶及其组织抑制物在子痫前期患者胎盘中的基因表达
mRNA expression of MMPs and TIMPs in placenta of preeclampsia
乔宠 1王春晖 2栾南南 1陈浩晹 1林其德 3尚涛1
作者信息
- 1. 中国医科大学附属第二医院,妇产科,辽宁,沈阳,110004
- 2. 沈阳军区总医院,辽宁,沈阳,11004
- 3. 上海第二医科大学附属仁济医院,上海,200080
- 折叠
摘要
Abstract
[Objective] To investigate the mRNA expressions of matrix metalloproteinase(MMP)-2,-9 and tissue inhibitior of metalloproteinase (TIMP)-1,-2 in placental tissue of patients with preeclampsia and their relation to the pathogenesis and development of preeclampsia. [Methods] Semi-quantitative RT-PCR analysis was used to detect the MMP-2, MMP-9, TIMP-1, TIMP-2mRNA expression levels in placental tissue of 50 cases of patients with preeclampsia ( 24 cases of mild and 26 cases of severe preeclampsia) and 30 cases of normalterm pregnant women.[Results] The MMP-9 gene expression level was significantly reduced in placental tissue of preeclampsia (P ＜0.01),which was the lowest in those of severe preeclampsia(0.07±0.05). With the development of preeclampsia, the MMP-2 gene expression level appeared a descent tendency without significance(P＞0.05). The expression of TIMP-1 mRNA were significantly higher in the placental tissue of severe preeclampsia patients than those of normal term (P ＜0.01),which was the highest in those of severe preeclampsia (1.49±0.21). The TIMP-2 gene expression level was significantly reduced in placental tissue of preeclampsia (1.14±0.36, P ＜0.01), which appeared a descent tendency with the severity of preeclampsia. [Conclusions] The expression of invasion related gene (MMP-2 and MMP-9) mRNA reduced and invasion suppressor gene (TIMP-1) mRNA increased with the development of preeclampsia. The expression of invasion related gene mRNA correlated with the severity of preeclampsia.关键词
蛋白酶/胎盘/子痫前期Key words
proteinase/placenta/preeclampsia分类
医药卫生引用本文复制引用
乔宠,王春晖,栾南南,陈浩晹,林其德,尚涛..基质金属蛋白酶及其组织抑制物在子痫前期患者胎盘中的基因表达[J].中国现代医学杂志,2005,15(22):3361-3365,5.
