中华医学杂志（英文版）2004，Vol.117Issue(3)：337-341,5.
Real-time three-dimensional myocardial contrast echocardiography in assessment of myocardial perfusion defects
Real-time three-dimensional myocardial contrast echocardiography in assessment of myocardial perfusion defects
CHEN Li-xin 陈立新 1YANG Ying 杨颖 1FEI Hong-wen 费洪文 2WANG Liang-yu 王良玉 2WANG Xin-fang 王新房 1Navin C Nanda 1Andrew P Miller 1XIE Ming-xing 谢明星 1ZHUANG Lei 庄磊 1YANG Ya 杨娅 1WANG Jing 王静 1HUANG Run-qing 黄润青1
作者信息
- 1. Department of Echocardiography,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
- 2. Division of Cardiovascular Disease,University of Alabama at Birmingham,Birmingham,Alabama 35249,USA
- 折叠
摘要
Abstract
Background Both real-time three-dimensional echocardiography (RT3DE) and myocardial contrast echocardiography (MCE) are novel imaging techniques. The purpose of this study was to confirm the feasibility and accuracy of RT3DE combined with MCE for quantitative evaluation of myocardial perfusion defects.Methods Thirteen dogs underwent ligation of the left anterior descending artery (LAD, n=6) or distal branch of the left circumflex artery (LCX, n=7) under general anaesthesia. Three to four ml of a perfluoropropane (C3F8) microbubble contrast agent was injected intravenously to assess the resulting myocardial perfusion defects with a commercially available Philips SONOS-7500 ultrasound system. After removal of the dog hearts, Evans blue dye was injected via the left and right coronary arteries to stain the myocardium at risk. In vitro anatomic measurements of myocardial mass after removal of the animals' hearts were used as controls.Results Left ventricular (LV) mass determined by RT3DE ranged 36.7-68.9 g [mean, (54.6±9.6) g] before coronary artery ligation, and correlated highly (r=0.99) with in vitro measurement of LV mass [range, 38.9-71.1 g; mean, (55.6±9.3) g]. There was no significant difference between RT3DE and in vitro measurements of LV mass [range, 36.7-68.9 g; mean, (51.3±12.5) g. Or range, 38.9-71.1 g; mean, (53.7±12.3) g, respectively] and under-perfused mass [range, 0-21.4 g; mean, (12.0±6.9) g. Or range, 0-19.8 g; mean, (10.8±6.3) g, respectively] after the LAD ligation (P>0.05). Likewise, no significant difference was present between RT3DE and in vitro measurements of LV mass [range, 50.1-65.4 g; mean, (57.5±5.9) g. Or range, 51.5-65.8 g; mean, (57.3±6.4) g, respectively] and under-perfused mass [range, 0-25.6 g; mean, (13.3±9.6) g. Or range, 0-22.7 g; mean, (12.8±8.1) g, respectively] after the LCX ligation (P>0.05). For all the animals with coronary ligation, LV mass measured by RT3DE ranged 35.9-68.6 g [mean, (54.8±10.0) g] and there was no significant difference between RT3DE and in vitro measurements of LV mass and under-perfused mass (P>0.05, r=0.99). Further, the under-perfused mass derived from RT3DE [range, 0-25.6 g; mean, (12.7±8.2) g] correlated strongly with the in vitro measurements [range, 0-22.7 g; mean, (11.9±7.2) g] (r=0.96). Conclusion RT3DE with MCE is a rapid and accurate method for estimating LV myocardial mass and quantifying perfusion defects.关键词
real-time three-dimensional echocardiography/myocardial contrast echocardiography/perfusion defects/myocardial infarctionKey words
real-time three-dimensional echocardiography/myocardial contrast echocardiography/perfusion defects/myocardial infarction分类
医药卫生引用本文复制引用
CHEN Li-xin 陈立新,YANG Ying 杨颖,FEI Hong-wen 费洪文,WANG Liang-yu 王良玉 ,WANG Xin-fang 王新房,Navin C Nanda,Andrew P Miller,XIE Ming-xing 谢明星,ZHUANG Lei 庄磊,YANG Ya 杨娅,WANG Jing 王静,HUANG Run-qing 黄润青..Real-time three-dimensional myocardial contrast echocardiography in assessment of myocardial perfusion defects[J].中华医学杂志（英文版）,2004,117(3):337-341,5.
