中国中西医结合杂志2001，Vol.21Issue(5)：339-341,3.
中药狼疮定对系统性红斑狼疮患者血清可溶性白细胞介素-2受体和新喋呤水平的影响
Effect of Langchuangding on Serum Soluble Interleukin-2 Receptor and Neopterin Level in Patients of Systemic Lupus Erythematosus
摘要
Abstract
Objective: In order to explore the therapeutic mechanism ofLangchuangding (LCD) in treating systemic lupus erythematosus (SLE) by observation of its effect on serum soluble interleukin-2 receptor (sIL-2R) and neopterin level in SLE patients. Methods: Forty-five patients of SLE were randomly divided into two groups, the 25 cases in the treated group were treated with LCD plus glucocorticoid (GCC) and the 20 cases in the control group were treated with GCC alone. The levels of sIL-2R and neopterin were observed before and after treatment by double antibody sandwich ELISA. Results: SLE patient showed higher levels of sIL-2R and neopterin than normal, and being higher in active stage than in remission stage. The level of neopterin was positively correlated with erythrocyte sedimentation rate (ESR) (r＝0.86, P＜0.01). After treatment, the levels of sIL-2R and neopterin were lowered significantly in the treated group than those in the control group (P＜0.05). Conclusion: LCD could effectively reduce the serum levels of sIL-2R and neopterin in SLE patients, which would be beneficial to cellular immune functional regulation and induce the disturbed internal environment of immunity to homeostasis.关键词
系统性红斑狼疮/可溶性白细胞介素-2受体/新喋呤/中药狼疮定分类
医药卫生引用本文复制引用
温成平,范永升,李学铭..中药狼疮定对系统性红斑狼疮患者血清可溶性白细胞介素-2受体和新喋呤水平的影响[J].中国中西医结合杂志,2001,21(5):339-341,3.基金项目
国家自然基金资助项目的部分内容(No.39870921) （No.39870921）
