中国临床康复2004，Vol.8Issue(17)：3422-3423,2.
补肾壮骨颗粒与联合激素替代疗法对骨代谢生化指标的影响
Effects of bushen zhuanggu granule and combined hormone replacement therapies on biochemical indexes of bone metabolism
摘要
Abstract
BACKGROUND: The changes of endocrine system and the descent of estrogen levels start in women since menopause, which would cause a series of syndromes and indicate that there are close relationships between menopausal women and, sex hormones and the biochemical indexes of bone metabolism,such as calcium and phosphorus, etc..OBJECTIVE: To observe the effect of bushenzhuanggu granule(tonifying the kidney-yang and strengthening bone) on the biochemical indexes of bone metabolism, such as calcium and phosphorus in menopausal forepart women.DESIGN: A complete randomized double-blinded grouping study was conducted.SETTINGS and PARTICIPANTS: The study was completed in the Department of General Medicine, Guangzhou General Hospital of Guangzhou Military Commond and Maternal and Child Care Hospital of Yuexiu District in Guangzhou. The subjects were 132 out-patient women in early menopause hospitalised in the two hospitals.METHODS: The 132 women were randomly divided into bushenzhuanggu group(granule group) with 63 women and replacement therapy group(control group) with 69 women, which were taken with bushenzhuanggu granule and,nilestriol and medroxyprogesterone acetate(MPA) orally, respectively. The sex hormones and and biochemical indexes of bone metabolism, such as calcium and phosphorus were assayed before and after treatment.MAIN OUTCOME MEASURES: Sex hormones levels, the changes of biochemical indexes, such as calcium and phosphorus.RESULTS: After 6-month treatment, estradiol(E2) (pmol/L) of granule group and control group were 158.71 ±39.72 and 189.15 ±36.71 respectively, and the ALP (μkat/L) were 1 070 ± 136 and 1119 ± 136 respectively with significant increases(t=2.002-2.712, P ＜ 0.05) .The ratios of urinary calcium to creatinine(Ca/Cr) were 0. 14 ±0.21 and 0. 15 ±0. 33 respectively with significant decreases( t = 2. 135 - 2. 164, P ＜ 0.05) .There were no significant differences in the comparisons of the indexes between two groups( t =0. 121, P ＞ 0.05).关键词
骨质疏松,绝经后/中药疗法/补肾壮骨颗粒/药理学/性激素类/血液/钙血液/磷血液Key words
Bushenzhuanggu granule has hormone-like reactions/which can elevate estrogen and ALP levels. It is a high efficient and safety traditional Chinese medicine agent in the prevention of the disorder of sex hormones and changes of bone metabolism after menop分类
医药卫生引用本文复制引用
邓伟民,沈有高,贺扬淑,韦蒿..补肾壮骨颗粒与联合激素替代疗法对骨代谢生化指标的影响[J].中国临床康复,2004,8(17):3422-3423,2.基金项目
广东省中医药管理局科研课题(97318) （97318）
