北京中医药大学学报2001，Vol.24Issue(1)：34-35,46,3.
草果知母汤在阻断点燃模型形成过程中对NMDA受体及其mRNA的影响
Effects of Caoguozhimu Decoction on NMDA Receptor and NMDAR1 mRNA in PTZ-Kindled Rat Model
摘要
Abstract
The effects of Caoguozhimu Decoction (CD), a TCM antiepileptic, on NMDA receptor binding capacity and the expression of NMDAR1 mRNA in pentylene tetrazole-kindled rat model were observerd by the ligand-receptor method and i n situ hybridization, with MK-801 as a contrast. The results showed that compar ed with model group, the level of hippocampal NMDAR1 mRNA was significantly decr eased (P<0.05) in CD group, while there was no obvious change of that in MK -801 group; and the cortical NMDA receptor binding capacity was obviously decreased but with out statistical significance in CD group, while there was a significant decrease (P<0.05) of that in MK-801 group. The results imply that CD decreases the level of NMDA receptor mainly by decreasing the expression of NMDAR1 mRNA.关键词
草果知母汤/癫痫模型/原位杂交/配基受体法/NMDA结合力分类
医药卫生引用本文复制引用
贺娟,梁怡,钱会南,王洪图..草果知母汤在阻断点燃模型形成过程中对NMDA受体及其mRNA的影响[J].北京中医药大学学报,2001,24(1):34-35,46,3.
