中国现代医学杂志2003，Vol.13Issue(19)：34-37,4.
膀胱移行细胞癌中E-Selectin、E-Selectin mRNA的表达结果及其临床意义的初步研究
EXPRESSION OF E-SELECTIN AND E-SELECTIN mRNA AND THE POTENTIAL CLINICAL IMPLICATIONS IN HUMAN BLADDER TRANSITIONAL CELL CARCINOMA
曾向阳 1范本祎 2孙芳浒 2张轶庠 2祖雄兵 2黄江波 2申鹏飞2
作者信息
- 1. 南华大学第二附属医院泌尿外科,衡阳,421001
- 2. 中南大学湘雅医院泌尿外科,长沙,410008
- 折叠
摘要
Abstract
Objective:To make a preliminary study of the expression of the E-Selectin mRNA and E-Selectin in bladder transitional cell carcinoma (BTCC), and then their possible clinic significance.Methods:32 fresh surgical specimens of BTCC were examined by immunohistochemistry for E-Selectin protein expression and in situ hybridization for E-Selectin mRNA expression. We discussed the correlation between the expression of E-Selectin mRNA, E-Selectin and tumor clinical stage and tumor pathological grade.Results:23/32 tumor specimens had positively expressed E-Selectin mRNA,20/32 tumor specimens showed positive E-Selectin expression. Abnormal expression of E-Selectin mRNA and E-Selectin had a significantly association with tumor clinical stage but not with increased tumor grade. 11 recurrent tumor specimens showed positive expression of E-Selectin mRNA, of which 10 tumors showed positive expression of E-Selectin. The abnormal expression had a significant association with tumor recurrence.Conclusions:The over- expression of E-Selectin and E-Selectin mRNA is frequent in BTCC. There is a significant correlation between the over-expression of E-Selectin, E-Selectin mRNA and metastasis , recurrence in BTCC.. The over-expression of E-Selectin and E-Selectin mRNA may be potential prognostic markers in BTCC.关键词
膀胱移行细胞癌 表达 浸润 转移 E-Selectin E-Selectin mRNAKey words
Bladder Transitional Cell Carcinoma/Metastasis/E-Selectin/E-Selectin mRNA/In Situ Hybridization/Immunohistochemistry分类
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曾向阳,范本祎,孙芳浒,张轶庠,祖雄兵,黄江波,申鹏飞..膀胱移行细胞癌中E-Selectin、E-Selectin mRNA的表达结果及其临床意义的初步研究[J].中国现代医学杂志,2003,13(19):34-37,4.
