摘要
Abstract
Objective To study the effect of low dose radiation on tumor growth and hormesis in erythrocyte system of tumor-bearing mice. Methods Kunming male mice were subcutaneously implanted with S180 sarcoma cells in the right inguen as an experimental animal model. Six hours before implantation, the mice were given 75 mGy whole body X-ray radiation. Tumor growth was observed five days later, and the tumor volume was calculated every other day to draw a tumor growth graph. Fifteen days later, all the tumors were removed and weighed, and the necrotic areas and tumor-infiltration-lymphoreticular cells (TILs) observed. At the same time, erythrocyte immune function, the level of 2,3-DPG and the activity of SOD were determined. Results The tumor growth slowed down significantly in mice pre-exposed to low dose radiation. The tumor necrotic areas were larger and TILs were more in the radiation group than in the group without radiation. The erythrocyte immune function, the level of 2,3-DPG and the activity of SOD in the low dose radiation group were higher than those of the group without radiation (P＜0.05). Conclusion Low dose radiation could markedly increase the anti-tumor ability of the organism and improve the erythrocyte immune function, the ability of carrying O2 and the activity of SOD in red blood cells.关键词
剂量效应关系,辐射/肉瘤180/免疫,细胞/2,3-DPG/超氧化物歧化酶Key words
dose-response relationship, radiation/sarcoma 180/immunity, cellular/superoxide dismutase/2,3-DPG分类
临床医学
