中药材2001，Vol.24Issue(5)：348-350,3.
血清药理学方法研究蛇葡萄素抗B16黑色素瘤的作用
Study on Inhibitory Effect of Ampelopsin on Melanoma by Serologic Pharmacological Method
刘德育 1罗曼2
作者信息
- 1. 中山医科大学广州 510089
- 2. 贵州省药品与生物制品检验所贵阳 550004
- 折叠
摘要
Abstract
Objective:To study the inhibitory effect of ampelopsin onmelanoma.Methods:Using a serologic pharmacological method,the inhibitory effects of different dose of ampelopsin on B16 melanoma cells were evaluated by a MTT assay and a flow cytometry.Results:The serums of C57BL/6 mices,which were administered by 0.420 mmol/kg dose and 0.560 mmol/kg dose of ampelopsin,could obviously suppress the B16 melanoma cells,and the inhibitory rate was equal to that of the vacant serum adding same consistency ampelopsin.The drug serums of the two doses groups reduced the cleavage and proliferation index of B16 melanoma cells to 19.1% and 21.7% respectively.Conclusion:Ampelopsin possibly acts on melanoma B16 cells by original form drug at the period with a peak of the drug concentration,and inhibits the DNA synthesis of B16 cells.关键词
蛇葡萄素 血清药理学 B16黑色素瘤细胞 抗癌作用分类
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刘德育,罗曼..血清药理学方法研究蛇葡萄素抗B16黑色素瘤的作用[J].中药材,2001,24(5):348-350,3.
