北京中医药大学学报2001，Vol.24Issue(3)：35,1.
仲景三方对大鼠肝纤维化不同时期血清Ⅲ型前胶原、
透明质酸及层粘蛋白作用的观察
Observation of the Effects of Dr. Zhang Zhongjing's Three Formulas on the Levels of Serum Procollagen Ⅲ, Hyaluronic Acid and Laminin in the Rats with Hepatic Fibrosis in Different Stages
任小巧 1卢跃卿 1陈永旭 1庞玉琴 1未志军 2田晨光2
作者信息
摘要
Abstract
An observation was made on the effects of Xiaochaihu Decoction, Dahuangzhechong Pills and Biejiajian Pills on serum procollagen Ⅲ (Pc Ⅲ), Hyaluronic Acid (HA) and laminin (LN) in different stages of rat hepatic fibrosis. The levels of Pc Ⅲ, HA and LN were determined in rat CCl4 hepatic fibrosis model by radioimmunoassay. The results showed that Xiaochaihu Decoction could obviously decrease the levels of serum LN and HA in the prevention of hepatic fibrosis, and could lower the level of HA in the treatment of minor hepatic fibrosis, which suggested that in the treatment of hepatic fibrosis, Xiaochaihu Decoction should be given in an early stage; Dahuangzhechong Pills could decrease the levels of serum HA, LN and Pc Ⅲ in the rats with hepatic fibrosis in every stages, which suggested that Dahuangzhechong Pills had therapeutic effects on hepatic fibrosis; although both preventive dose and therapeutic dose of Biejiajian Pills could decrease the level of serum HA, only the therapeutic dose could decrease the levels of serum LN and Pc Ⅲ, but at the same time it brought unfavorable effects on the rats, which suggested that Biejiajian Pills had no good preventive effects on hepatic fibrosis, and the measures for keeping and maintaining the vitality of the body should be adopted when to use Biejiajian Pills clinically, because they could damage the vitality of the body despite their therapeutic effects.关键词
仲景三方/肝纤维化/大鼠/血清/HA/LN/PCⅢ分类
医药卫生引用本文复制引用
任小巧,卢跃卿,陈永旭,庞玉琴,未志军,田晨光..仲景三方对大鼠肝纤维化不同时期血清Ⅲ型前胶原、
透明质酸及层粘蛋白作用的观察[J].北京中医药大学学报,2001,24(3):35,1.
