中国人兽共患病杂志2001，Vol.17Issue(1)：3-5,3.
肾综合征出血热I型疫苗中期流行病学效果研究
STUDY ON THE MIDDLE-TERM EPIDEMIOLOGICAL EFFICACY OF VACCINES AGAINST HFRS
摘要
Abstract
Aim Observe the safety and epidemiological efficacy character ofHFRS vaccine in the focus population with high incidence of HFRS in Zhejiang province.Methods Immunofluorecent antibody assay was used in testing specific IgG antibody and Mcro-CPE Method was used in testing the titer of neutralizing antibody.Result 10460 people were vaccinated ,97.30% of them completed their vaccination with full doses.16 159 non -vaccinated people living in the same areas as the control group. Two weeks after the injection , the seroconversion rate by Immunofluorecent antibody test(IgG) and neutralization test were 100.00%(67/67) and 44.44%, the GMTs of them were 72. 14 and 4.63 respectively.Before reinforce,the rate of seroconversion of immunofluorescent antibody by IFA method and the rate of seroconversion of neutralizing antibody by the Mcro-CPE method were all low.After reinforce,the rates of seroconversion of immunofluorescent antibody and neutralizing antibody were all going up.But they all droped again after one year,the reaction of vaccine was little.The vaccinated group had no patient and the control group had 24 patients and 3 died. According to the middle-term(4 years after primary immunization) observation, the vaccine was effective,and its protection rate in population was 100.00%(95% CI is 96.3%～100%).We have found some antibodies dependent on immunization enhancement phenomenon among the inoculated population,but still need to observe.Conclusion HFRS vaccine has a well effect in epidemiology in the middle-term.关键词
肾综合征出血热/灭活疫苗/预防接种分类
医药卫生引用本文复制引用
龚震宇,翁景清,赵芝雅,傅桂明,朱智勇,夏建华,兰锦清,陈毓土,林成巨,季群伟,徐江荣,汪垂章,余新顺,王玮,方春福..肾综合征出血热I型疫苗中期流行病学效果研究[J].中国人兽共患病杂志,2001,17(1):3-5,3.基金项目
国家九五医学科技攻关课题的一部分(96-906-03-13) （96-906-03-13）
