中华医学杂志（英文版）2004，Vol.117Issue(3)：353-356,4.
Astrovirus infection in young children with diarrhea hospitalized at Beijing Children's Hospital
Astrovirus infection in young children with diarrhea hospitalized at Beijing Children's Hospital
刘春艳 1申昆玲 1王树欣 1刘亚谊 1照日格图2
作者信息
- 1. Beijing Children's Hospital,Capital University of Medical Sciences,Beijing 100045,China
- 2. China Medical Tribune,Beijing 100009,China
- 折叠
摘要
Abstract
Background This study was to assess certain epidemiological and clinical characteristics of astrovirus infection in children with diarrhea below 5 years old hospitalized at the Beijing Children's Hospital.
Methods From September 1999 to August 2001, a total of 288 children with diarrhea below 5 years old hospitalized at Beijing Children's Hospital were studied. Fecal specimens collected from each patient were tested for astrovirus by using enzyme immunoassay (EIA) and further serotyped by reverse-transcription polymerase chain reaction (RT-PCR) using serotype-specific primers.
Results Astrovirus antigen was positive in 9.0% of the patients, and the rate of coinfection with rotavirus was 19.2% among the astrovirus positive patients. The patients with astrovirus infection were at the age of 7 days to 17 months, most (92.3%) of them were less than 12 months. Astrovirus infection occurred mainly between October and March of the following year. Main symptoms included watery stool, vomiting, fever, and dehydration. Increased activity of myocardial enzyme was seen in 4 patients. Of the 22 astrovirus positive specimens, 14 were successfully serotyped by RT-PCR and they were all serotype 1.
Conclusions The overall incidence of astrovirus infection in young children with diarrhea hospitalized at the Beijing Children's Hospital was 9.0%. The predominant serotype was type 1. Astrovirus may play an important role in viral diarrhea in young children in Beijing, China.
关键词
astrovirus/diarrhea/childrenKey words
astrovirus/diarrhea/children分类
医药卫生引用本文复制引用
刘春艳,申昆玲,王树欣,刘亚谊,照日格图..Astrovirus infection in young children with diarrhea hospitalized at Beijing Children's Hospital[J].中华医学杂志（英文版）,2004,117(3):353-356,4.
