口腔颌面外科杂志2001，Vol.11Issue(1)：35-37,3.
聚乳酸及其复合物修复下颌骨缺损的实验研究
THE EXPERIMENTAL STUDY OF REPAIRING THE MANDIBULAR BONE DEFECT USING PLA-rhBMP-2
黄相道 1刘境华 2赵明 3王会信3
作者信息
- 1. 吉林省延边大学医学院附属医院口腔科
- 2. 白求恩医科大学 口腔医学院口腔颌面外科
- 3. 军事医学科学院基础医学研究所
- 折叠
摘要
Abstract
Purpose A new synthetic material consists of Polylac tic acid[PLA] and recombinant human bone morphogenetic protein-2[PLA-rhBMP -2]. The capacity of repairing bone defect of biodegradable PLA and the effica cy of PLA as a carrier for bone morphogenetic protein [BMP] are determined wit h detecting the osteogenetic process. Materials and Methods Eighteen rabbits were picked up and divided i nto three groups randomly. The defects of 12mm×6mm size were made at bilateral mandibul ar edges. PLA-rhBMP-2, PLA were implanted in the defect respectively. The 18 r abbits were killed at 2,4,8 and 12 weeks after implanting. The sample was analyz ed by the methods of X-rays and histological examination. Results After 2 weeks, the new bone began to form in the defects. A fter 8 weeks, bulk bone could be obviously observed. After 12 weeks, most of the PLA in the defects were already biodegraded. The defects were restored with n ew bone. The results in PLA-rhBMP-2 group were better than those of other grou ps. Conclusions PLA could be a promising carrier for BMP. PLA-rhBM P-2 has also been considered a better biodegradable material for repairing mand ibular defect.关键词
聚乳酸/人骨形成蛋白-2/骨缺损/下颌骨分类
医药卫生引用本文复制引用
黄相道,刘境华,赵明,王会信..聚乳酸及其复合物修复下颌骨缺损的实验研究[J].口腔颌面外科杂志,2001,11(1):35-37,3.
