南京医科大学学报(英文版)2003，Vol.17Issue(1)：35-39,5.
吸入肝素对哮喘豚鼠气道炎症影响的研究
Bronchoalveolar Lavage and Histologic Characterization of Inhaled Heparin in Asthmatic Guinea Pigs
谷伟 1孙丽华 1乔岩 1陶臻 1邵宏涛 1毛山 1季寿琪1
作者信息
- 1. 南京医科大学附属南京第一医院呼吸科,南京,210006,中国
- 折叠
摘要
Abstract
Objective:To survey the effects of inhaled heparin on airway inflammation inguinea pigs with asthma and investigate the possible mechanism of inhaled heparin in the treatment of asth-ma. Methods:The asthma in guinea pigs induced by ovalbumin was treated with inhaled heparin. Thechanges of cellularities in bronchoalveolar lavage ( BAL ) fluid and the airway walls were examined. His-tologic examinations were also done in the guinea pig controls. Results: The number of eosinophils, lym-phocytes, and ciliated epithelial cells in the BAL fluid from the group treated with heparin was significant-ly lower than that of the group of asthma controls ( P ＜ 0. 01). Within the airway walls of the heparintreated group, the eosinophil infiltration was less prominent than that of the group of asthma controls(P＜0. 001) and the number of mast cell was significantly higher than that of the group of asthmacontrols ( P ＜ 0. 01). Histologic examination showed that airway damages in the heparin treated groupwere mild. Conclusion : Heparin can inhibit airway inflammation and alleviate airway damage inguinea pigs with asthma.关键词
肝素/动物模型/哮喘/气道炎症/豚鼠Key words
heparin/animals/asthma/airway inflammation/guinea pigs分类
医药卫生引用本文复制引用
谷伟,孙丽华,乔岩,陶臻,邵宏涛,毛山,季寿琪..吸入肝素对哮喘豚鼠气道炎症影响的研究[J].南京医科大学学报(英文版),2003,17(1):35-39,5.
