中国药房2001，Vol.12Issue(6)：356-357,2.
奥美拉唑胶囊人体药代动力学及相对生物利用度研究
Study on the Pharmacokinetics and Relative Bioavalability of Omeprazole Capsules in Humans
左六一 1刘贵娟 1邱峰 2何海霞 2周远大2
作者信息
- 1. 重庆医科大学附属第一医院药剂科,
- 2. 重庆医科大学附属第一医院临床药理研究室,
- 折叠
摘要
Abstract
OBJECTIVE： To study the pharmacokinetics and relative bioavalability of omeprazole capsules in humans.METHODS： 18 male healthy volunteers orally took domestic omeprazole capsules and losec capsulles(used as control)40mg respectively.Blood concentrations of drugs were determined by HPLC.RESULTS： Times to reach the peak levels of omeprazole and losec were （2.10± 0.64） h and （1.88± 0.70） h， the peak plasma concentrations were （895.64± 553.07） ng/ml and （974.67± 554.93） ng/ml and the areas under the drug concentration curves were （1 971.88± 1 220.98 ） ng/（h· ml） and （2 057.60± 1 306.32） ng/（h· ml） respectively.CONCLUSION： The two capsules have the same bioequivalence.关键词
奥美拉唑/生物利用度/高效液相色谱法分类
医药卫生引用本文复制引用
左六一,刘贵娟,邱峰,何海霞,周远大..奥美拉唑胶囊人体药代动力学及相对生物利用度研究[J].中国药房,2001,12(6):356-357,2.
