中国循证儿科杂志2009，Vol.4Issue(4)：356-361,6.DOI:10.3969/j.issn.1673-5501.2009.04.006
与食用受三聚氰胺污染配方奶粉相关儿童泌尿系统结石的现况调查
A field survey of the relationship between feeding melamine-contaminated powdered formula and urolithiasis in children
李颖杰 1陈嘉慧 1谢国麟 1邱绣 1高岩 1钟桴 1邓颖敏 1杨华彬 1邓会英 1叶红 1钟发展1
作者信息
- 1. 广州市妇女儿童医疗中心儿童医院,广州,510120
- 折叠
摘要
Abstract
Objective To investigate the relationship between melamine-contaminated powdered formula and urolithiasis of children in China. Methods We administered a questionnaire including sex, age, melamine content, physical examination, urinalysis, ultrasonography in urinary system, renal function, liver function, blood, urinary tests for biochemical markers and so on to the doctors and parents of children aged from 0 to 14 years who were screened for a history of exposure to melamine-contamin atedpowdered formula- Symptoms and possible predisposing factors of urinary tract stones were collected as well. Melamine-contaminated contaminated powdered formula, the children were divided into two groups, more than 30 days group and less than 30 days group. The morbidity of urolithiasis was analyzed in different melamine content and different feeding period children including less than 1 year old, -2 years old, -3 years old, -6 years old and -14 years old. The clinical symptoms, laboratory results and recovery rate were also analyzed. SPSS 11.5 was used for statistical analysis. Results 22 091 children were screened and urinary stones were found in 374 children,including 223 boys and 151 girls(P <0. 001 ). The high melamine content group had a higher morbidity of urinary tract stones than the low melamine content group in children less than 3 years old children( P <0. 001 ). Similar tread was seen in children aged 3 to 6 years old children(P <0. 05), but no difference in children aged from 6 to 14 years old children(P > 0. 05 ). Within the high melamine content group, the morbidity of urinary tract stones was similar with each other at different ages (P > 0. 05 ). Within the low melamine content group, the morbidity of urinary tract stones was also similar with each other at different ages( P >0. 05 ) except for children aged less than 12 months and 12 to 24 months old children( P > 0.05 ). Among the total of 374 cases that were found urinary tract stones,369 were kidney stenes(309 in one side and 60 in both sides) ,8 w ere ureterstones(6 in one side and 2 in both sides) ,4 were cystolith and 2 were urethral calculus. 93 patients were admitted to the ho spital,of them 8 cases had hematuria (8. 6% ), 7 cases had leukocyturia, 3 cases had proteinuria (3.2%), 5 cases had crying on urination (5.4%), 2 cases had edema (2. 2% ) . Laboratory tests:2S eases had elevated blood β<,2>-MG (26. 9% ), 4 had elevated urineβ<,2>-MG(4. 3% ) , 2 had elevated serum creatinine and urea nitrogen(2. 2% ). There was no patient with elevated levels of CK-MB and ALT. 9 of the 93 patients received surgical treatment. 34 patients were cured, 55 got better, and 2 were unrecovered. Conclusions Melamine-contaminated powdered formula was associated with urinary tract stones in children. The morbidity of urolithiasis might not be associated with age. The urolithiasis was prohable harmful to kidney function.关键词
儿童/泌尿系统结石/三聚氰胺Key words
Children/Urolithiasis/Melamine分类
医药卫生引用本文复制引用
李颖杰,陈嘉慧,谢国麟,邱绣,高岩,钟桴,邓颖敏,杨华彬,邓会英,叶红,钟发展..与食用受三聚氰胺污染配方奶粉相关儿童泌尿系统结石的现况调查[J].中国循证儿科杂志,2009,4(4):356-361,6.
