中国病理生理杂志2003，Vol.19Issue(3)：357-360,4.
星形细胞瘤中PTEN、Mdm2和p53的表达及其相关性研究
The expression and relationship of PTEN, Mdm2 and p53 in human astrocytoma
摘要
Abstract
AIM: This investigation was done to show the incidence of PTEN, Mdm2 and p53 expression in different histopathological grades of astrocytoma and the mechanisms of signal transduction through which PTEN affects Mdm2 and p53 expression. METHODS: The surgical specimens from 68 brain astrocytoma patients were analysed to detect PTEN, Mdm2 and p53 expression with immunohistochemical method. RESULTS: The incidence of PTEN, Mdm2 and p53 expression was 54.4%(37/68), 41.2%(28/68) and 45.6%(31/68) respectively in astrocytoma. The positive incidence of Mdm2 protein in 37 cases with PTEN positive expression was 24.3% (9/37) and in 31 cases with PTEN negative expression was 61.3%(19/31).There was an inverse correlation between Mdm2 expression and PTEN expression(P＜0.01). 18 cases showed Mdm2+/p53+ expression and 27 cases showed Mdm2-/p53- expression. A significant correlation was found between Mdm2 and p53 expression(P＜0.05).CONCLUSIONS: These findings strongly indicated that (1) There was a correlation between histopathological grade of astrocytoma and loss of PTEN expression, Mdm2 expression, p53 expression and (2) PTEN expression inhibited Mdm2 expression and (3) Mdm2 expression was in accordance with p53 expression.关键词
星形细胞瘤/蛋白质p53/信号转导/免疫组织化学Key words
Astrocytoma/Protein p53/Signal transduction/Immunohistochemistry分类
医药卫生引用本文复制引用
孙艳花,钟雪云,陈运贤..星形细胞瘤中PTEN、Mdm2和p53的表达及其相关性研究[J].中国病理生理杂志,2003,19(3):357-360,4.基金项目
Supported by science foundation of Guangzhou(2001-Z-03-01-2),Science Team Foundation of Guangdong(015012)and the Projects of Development Plan of the State Key Fundamental Research(2002ccc0400) （2001-Z-03-01-2）
