中国药房2001，Vol.12Issue(6)：358-359,2.
谷氨酰胺颗粒剂对严重烧伤患者的疗效及安全性分析
Analysis of the Efficacy and Safety of L-Glutamine Granules in Treating Severe Burn Patients
摘要
Abstract
OBJECTIVE： To evaluate the clinical therapeutic effect of L-glutamine granules on intestinal damage of severe burn patients and the safty of the drug.METHODS： Thirty-nine severe burn patients were randomly divided into two groups： control group（C group， nineteen patients） and L-glutamine treatment group（GLN group， twenty patients） .GLN group patients were given L-glutamine in a dose of 30g per day for 7 days， and C group patients were given the same dosage of placebo for 7 days.The plasma L-glutamine concentration， the degree of intestinal mucosa damage， blood biochemistry and complication were observed and wound healing rate of burn area was determined， then the length of hospital stay was recorded.RESULTS： After 7 days of taking L-glutamine orally， plasma L-glutamine concentration in GLN group was significant higher than that in C group（P<）. The degree of intestine damage and intestinal mucosal permeability in GLN group were lower than those in C group. In addition, the wound healing rate was faster and the length of hospital stay was shorter in GLN group than those in C group. CONCLUSION: Administration of L-glutamine could abate the degree of intestine damage obviously, lessen intestinal mucosal permeability, ameliorate wound healing rate and reduce the length of hospital stay.关键词
谷氨酰胺/肠粘膜屏障/创面愈合/烧伤分类
医药卫生引用本文复制引用
彭曦,尤忠义,王风君,陶凌辉,赵云,贺光照,果磊..谷氨酰胺颗粒剂对严重烧伤患者的疗效及安全性分析[J].中国药房,2001,12(6):358-359,2.基金项目
基金项目：本文为曾获军队科技进步一等奖（96-1-8-1）和国家科技进步二等奖（15-2-008-01）科研项目的部分内容 （）
