首页|期刊导航|中华医学杂志（英文版）|Pre-clinical atherosclerosis evaluated by carotid artery intima-media thickness and the risk factors in children
中华医学杂志（英文版）2007，Vol.120Issue(5)：359-362,4.
Pre-clinical atherosclerosis evaluated by carotid artery intima-media thickness and the risk factors in children
Pre-clinical atherosclerosis evaluated by carotid artery intima-media thickness and the risk factors in children
摘要
Abstract
Background Atherosclerosis as a cardiovascular disease was found to begin even in the fetal period. However,information about risk factors of pre-clinical atherosclerosis in childhood has been limited. Hence, this study was aimed to find out the risk factors of atherosclerosis by measuring the carotid artery intima-media thickness in children. High resolution B-mode ultrasound used to examine the carotid artery intima-media thickness was demonstrated to be useful in finding the early carotid structural changes.Methods The study included 79 children who were divided into two groups according to their ages: group Ⅰ consisted of 42 children with ages from 5 to 9 years and group Ⅱ consisted of 37 children with ages from 10 to 18 years, Among them,23 had a positive family history for risk, such as hypertension, obesity or dyslipidemia. Blood samples were collected and total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein were assayed. The carotid artery intima-media thickness was measured by ultrasound. Comparisons were done between the two groups using Student's t tests and Chi-square analysis. Body mass index, blood pressure, levels of lipids, family history and the carotid artery intima-media thickness were calculated by conditional logistic regression analysis.Results Compared with the children without a positive family history, the incidence of the increased carotid artery intima-media thickness was significantly high (x2=4.364, P＜0.05). There were no statistically significant differences between left and right carotid arteries in carotid artery intima-media thickness (P＞0.05). In this study, diastolic blood pressure and the atherosclerosis index were suggested to be the risk factors to the thickened carotid artery intima-media thickness. In group I the diastolic blood pressure's odds radio was 1.187 (P=0.035) and the atherosclerosis index odds radio was 37.165 (P=0.001); in group Ⅱ the diastolic blood pressure's odds radio was 1.371 (P=0.009) and the atherosclerosis index odds radio was 30.724 (P=0.015).Conclusion The diastolic blood pressure and atherosclerosis index were the risk factors in pre-clinical arthrosclerosis.Regularly monitoring the high-risk children for the development and progression of vascular lesion would be of great value in avoiding and preventing cardiovascular disease.关键词
intima-media thickness/ atherosclerosis/ risk factors/ childrenKey words
intima-media thickness/ atherosclerosis/ risk factors/ children分类
医药卫生引用本文复制引用
YANG Xiao-zheng,LIU Ying,MI Jie,TANG Chao-shu,DU Jun-bao..Pre-clinical atherosclerosis evaluated by carotid artery intima-media thickness and the risk factors in children[J].中华医学杂志（英文版）,2007,120(5):359-362,4.基金项目
This work was supported by grants from the Key Science and Technology Program of Beijing (No. H030930030530 and No.H030930030031), and Major Basic Research Project of China (No.2006CB503807). （No. H030930030530 and No.H030930030031）
