中德临床肿瘤学杂志（英文版）2009，Vol.8Issue(6)：360-365,6.DOI:10.1007/s10330-009-0023-9
细胞内吞作用的研究进展
Study progress of cell endocytosis
摘要
Abstract
Endocytosis is a process through which extracellular materials are transported into cell through membrane defor-mation. This process is not a simple step-by-step process in which a series of proteins function according to the chronological order, but rather a complex process comprising many members which are regulated precisely. The role of endocytosis is broadly divided into two categories, phagocytosis and pinocytosis, the latter is divided into four species in accordance with the size of endocytosis substances: dathrin dependent endocytosis, the diameter of dathrin-coated vesicle is 100-150 nm; caveolin dependent endocytosis, the diameter of caveolin protein-coated vesicle is 50-100 nm; macropinocytosis, the diam-eter of macropinocytosis is generally 0.5-2 μm, sometimes up to 5 pro; clathrin and caveolin independent endocytosis. Many proteins including endophilin A1, A2, A3, and endocytotic proteins B, Bla, and B1b as well as dynamin, acUn and Rab protein families are involved in endocytosis and play an important role in different stages. The abnormal endocytosis may be involved in the development of certain diseases.关键词
endocytosis/clathdn/caveotin/endophilin/signalling pathwayKey words
endocytosis/clathdn/caveotin/endophilin/signalling pathway分类
医药卫生引用本文复制引用
Li Chen,Hui Li,Ren Zhao,jianwei Zhu..细胞内吞作用的研究进展[J].中德临床肿瘤学杂志（英文版）,2009,8(6):360-365,6.基金项目
Supported by grants from the National Natural Sciences Foundation of China (No. 30771126 and 30772106). （No. 30771126 and 30772106）
