现代康复2001，Vol.5Issue(10)：36-37,2.
烧伤后不同类型胶原在增生性瘢痕发生中的作用研究
The function of different collogens in hypertrophic scars
摘要
Abstract
Objective The aim of this study was toinvestigate the dynamic changes of collagen Ⅰ and Ⅲ in the formation of hypertrophic scar afterbum. Method The sirius red and polarizationmicroscopy was used to detected the collagen Ⅰ and Ⅲ fibers in scar tissues in vary periods. Radial immunology assay methods were used to evaluatethe contents of procollagen Ⅰ and Ⅲ in vary periodsin HS tissue. Result Collagen Ⅲ fiber is the main collagen in normalskin. There were no collagen fibers been found in granulation tissue. Collagen Ⅰ increased significantly in scar tissue 1 month after burn, increased much more in 3 months than in 1 month. The collagen were nearly thick collagen Iin HS tissue 1.5 year afterburn and only a little collagen Ⅲ were found. The RIA result showed that the ratio of procollagen Ⅰ/Ⅲ were increased gradually but the contents of collagen Ⅲ were much higher than normal skin. Conclusion In the process of HS forming after burn collagen Ⅰ increase and collagen Ⅲ decrease gradually and at last the collagens in HS were almost collagen Ⅰ. The zchanges of procollagcn can not reflect the changes of collagen fibers.关键词
增生性瘢痕/Ⅰ型胶原纤维/Ⅲ型胶原纤维/前胶原分类
医药卫生引用本文复制引用
刘策励,赵雄飞,黎鳌,李世荣..烧伤后不同类型胶原在增生性瘢痕发生中的作用研究[J].现代康复,2001,5(10):36-37,2.
