中国病理生理杂志2001，Vol.17Issue(1)：36-39,4.
低氧大鼠血清和肺小动脉壁胰岛素样 生长因子-I的变化
Changes in IGF-I levels in serum and pulmonary arterioles of rats with hypoxic pulmonary hypertension
林勇 1陈文彬 2程德云1
作者信息
- 1. 华西医科大学附属第一医院呼吸内科， 四川 成都 610041
- 2. 东南大学附属中大医院呼吸内科（江苏 南京 210009
- 折叠
摘要
Abstract
AIM： To study changes in IGF-I concentration in serum, IGF-Ipolypeptide in the wall of pulmonary arterioles during hypoxia and the relationship between their changes and hypoxic pulmonary hypertension. METHODS: Morphological change in pulmonary arterioles was determined by image pattern analysis technique, the concentration of IGF-I in the rat serum was measured by radioimmunoassay. The expression of IGF-I polypeptide was observed by immunohistochemical staining on the walls of pulmonary arterioles, and analyzed quantitatively. RESULTS: After exposing hypoxia for 3 weeks, mPAP of rats was elevated(P＜0.01), and the walls of pulmonary arterioles in the rats with hypoxic pulmonary hypertension were observed to be thickened with both MT％ and MA％ higher significantly than those of normal (P＜0.05, respectively). The gray scale value of gray scale scanning in the pulmonary arterioles in the hypoxic rats was higher than that in the normal rats(P＜0.01). The level of IGF-I in serum in the hypoxic rats was higher than that in the normal rats (P＜0.05). The level of IGF-I in the rat serum was positively correlated with mPAP(r=0.745, P＜0.01). CONCLUSION： Under the hypoxic condition, IGF-I polypeptide production increased in the walls of pulmonary arterioles. Results implied that IGF-I stimulates vascular smooth muscular cell proliferation not only in autocrine and paracrine manner, but also in the endocrine manner.关键词
低氧/高血压,肺性/胰岛素样生长因子I分类
医药卫生引用本文复制引用
林勇,陈文彬,程德云..低氧大鼠血清和肺小动脉壁胰岛素样 生长因子-I的变化[J].中国病理生理杂志,2001,17(1):36-39,4.
