基础医学与临床2001，Vol.21Issue(1)：36-39,4.
多巴胺受体两个亚家族对大鼠背根神经节GABAA受体的影响
Effect on D1-Like and D2-Like agonist on GABAA-receptor in rat dorsal root ganglion
摘要
Abstract
The experiment was performed on neurons freshly isolated from rat DRG by using whole cell patch clamp techniques. When 60 cells responded to GABA were treated with SKF38393, a selective agonist of dopamine Dl receptor, it was found that except one cell which exhibited a slight potentiation( l0.0%,l/60), the inhibition by SKF38393 of GABA-activated current was predominant (88.33%,53/60), while the remainders were of no effect( l.66%,6/60). In 50 neurons tested , when the neurons were treated with R(-)-NPA prior to the application of GABA for 30sec, It was found that GABA-activated membrane currents were inhibited (76%,38/50) , enhanced (2%,l/50) , no effected markedly (22%,11/50). The effect of SKF38393 and R(-)-NPA was dependent on the concentration of SKF38393 and R(-)-NPA . By intracellular application of 10-4mol/L H7, a potent inhibitor of protein kinase , via micropipette the inhibition of SKF38393 and R(-)-NPA was abolished apparently as compared with the control .关键词
背根神经节/全细胞膜片钳记录/SKF38393/R(-)-NPA/γ-氨基丁酸分类
医药卫生引用本文复制引用
李琴,程汉兰,李之望..多巴胺受体两个亚家族对大鼠背根神经节GABAA受体的影响[J].基础医学与临床,2001,21(1):36-39,4.基金项目
国家自然科学基金资助(39370239) （39370239）
