中华医学杂志（英文版）2003，Vol.116Issue(3)：364-367,4.
Estrogen receptor gene polymorphisms and bone mineral density in Chinese postmenopausal women
Estrogen receptor gene polymorphisms and bone mineral density in Chinese postmenopausal women
刘建民 1朱汉民 2朱晓颖 2戴蒙 3江凌 3许曼音 1陈家伦1
作者信息
- 1. Department of Endocrinology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
- 2. Department of Geriatrics, Shanghai Huadong Hospital, Shanghai 200040, China
- 3. Shanghai Institute of Endocrinology, Shanghai 200025, China
- 折叠
摘要
Abstract
Objective To investigate the relationships between the polymorphisms of estrogen receptor (ER) gene, bone mineral density (BMD) and bone biochemical markers in Chinese postmenopausal women. Methods BMD of lumbar spine and femoral neck were measured using dual-energy X-ray absorptiometry (DEXA)in 186 Chinese postmenopausal women. The PvuⅡ and XbaⅠ polymorphisms of the ER gene were detected using polymerase chain reaction (PCR). Bone biochemical markers, serum alkaline phosphatase, osteocalcin and pyridinoline were measured by ELISA. Results The femoral neck(FN) BMD (Z score) was higher in pp compared to Pp (-0.01±0.12 vs. -0.35±0.09, P<0.05) while lumbar spine BMD (Z score) was higher in XX type compared to Xx and xx genotypes (0.01±0.45 vs -1.53±0.17, -1.29±0.10, P<0.001 and 0.001, respectively). Women without Px haplotype (n=79) had a higher BMD Z-score for the lumbar spine (-1.03±0.14 vs -1.45±0.11, P<0.05) and femoral neck (-0.01±0.11 vs -0.31±0.09, P<0.05) than those who had it (n=107). Conclusions The present study suggested that the pp and XX genotypes of ER gene might play a certain role in maintaining FN and lumbar spine BMD. ER genotypes without Px haplotype might be favorable to bone mass, while those with it might exert some harmful effect on bone mineral density. 关键词
bone mineral density/estrogen receptor gene/polymorphism/postmenopausal osteoporosisKey words
bone mineral density/estrogen receptor gene/polymorphism/postmenopausal osteoporosis分类
医药卫生引用本文复制引用
刘建民,朱汉民,朱晓颖,戴蒙,江凌,许曼音,陈家伦..Estrogen receptor gene polymorphisms and bone mineral density in Chinese postmenopausal women[J].中华医学杂志（英文版）,2003,116(3):364-367,4.
