中国组织工程研究与临床康复2007，Vol.11Issue(18)：3653-3656,4.
组织工程材料表面拓扑结构对其细胞相容性的影响
Topology of tissue engineering material surface for cell compatibility
摘要
Abstract
BACKGROUND:To clarify the effects of topology of tissue engineering material surface on cell compatibility from random roughness.porosity,groove/ridge, fiber,texture and protein tracks 6 aspects. STUDY SOURCES: Using the terms"biocompatibility,biocompatibility materials,tissue engineering,tissue engineering materials.cell-compatibility and cell-compatibility materials",we searched the PUBMED database to identify studies published in the English language from January 1987 to January 2007. STUDY SELECTION:The data were selected primarily.The quotations in each paper ware looked for.Inclusive criteria: The contents stated in papers were related with biocompatibility of tissue engineering material. Exclusive criteria: repetitive study or Meta analysis papers.DATA EXTRACTION:Totally 74 related papers were collected.Thirty-two met inclusive criteria,among which,24 related with biocompatibility and 8 related with cell-compatibility materials.The other 42 papers were excluded due to obsolete or repetitive contents. DATA SYNTHESIS:①The interaction of tissue engineering material and living body:Various Interactions producing when high polymer tissue engineering material contacts with tissue of living body are reviewed. It js pointed out that the interaction of material and living body depends on the biocompatibility degree of material;The influences of materials on histocompatibility include microscopic molecular level and macroscopic scale level,moreover,the effect of macroscopic scale level (include the topology of material surface) is more important than chemical effect of microscopic molecular level.②Effects of physical and chemical properties on cell-compatibility of materials:The effects of topology of surface of random roughness,porosity,groove/ridge,fiber, texture and protein tracks 6 kinds of materials on cell-compatibility are reviewed. It is also pointed out that the influences are very important in studying the biocompatibility of tissue engineering material and designing tissue compatibility materials.CONCLUSION:Topology of material surface has great influences on cell-compatibility of material.The interaction of cells and polymer is an index to evaluate cell-compatibility of material.Short-term interaction degree of cell and polymeric material can be assessed by detecting the adhesion degree of cells and polymeric material surface,while long-term interaction by detecting the growth of cells cultured in vitro or polymeric material implanted in vivo.关键词
生物相容性/生物相容性材料/组织工程/组织工程材料/细胞相容性/细胞相容性材料/综述文献分类
医药卫生引用本文复制引用
陈宝林,王东安,封麟先..组织工程材料表面拓扑结构对其细胞相容性的影响[J].中国组织工程研究与临床康复,2007,11(18):3653-3656,4.基金项目
Scientific Research Program of Universities in Nei Monggol Autonomuous Region, NJ06032 （）
内蒙古自治区高等学校科学研究项目(NJ06032) （NJ06032）
