摘要
Abstract
BACKGROUND: Research on coronary heart disease(CHD) mediator based on molecular biology is scarce, however, it is very helpful for the prevention and control of CHD on that level.OBJECTIVE: To find out the changes of plasma cyclic nucleotide in individuals of different behavior types so as to provide prospective data for the research of mediator of psychological factors inducing CHD.DESIGN: A prospective study.SETTING, PARTICIPANTS and INTERVENTION: Type A and Bbehaviour examinees, 19 respectively, were selected at random from 300 volunteers by questionnaire. Their venous bloods were collected at 16:30 to 17:00 80 days and 1 hour before examination respectively in Weifang First Middle School. Content of plasma cyclic nucleotide were assayed to observe the effect of psychological stress (university entrance examination is the stress origin) on individuals in different behavior types.MAIN OUTCOME MEASURES: Content of plasma cyclic nucleotide before and after stress respectively.RESULTS: Beforo the stress, content of plasma cyclic adenosine monophosphate(cAMP) [ (15.46 ± 3.56) nmol/L] of type A was significantly higher than type B[ (12.09 + 2.78) nmol/L], and this distinction had quite remarkable meanings( t = 3.25, P ＜ 0. 01 ). After the stress, the plasma cAMP and cAMP/cGMP content in type A decreased compared with that before strcss[ (10.911 +3.950), (5.526 + 1.488) nmol/L respectively], and the differeces were significant( t = 12. 25, 8. 14, P ＜ 0. 001), meanwhile, cGMP increased[ (2. 962 + 0. 764)nmol/L] ( t = - 9.06, P ＜ 0. 001 ); the plasma cAMP and cAMP/cGMP in type B decreased[ (7.379 ± 1.762), (3.677 ±1.488) mmol/L] (t =7.42, 7.56, P ＜ 0.001), while cGMP increased [ (2.280 ± 0.685 ) nmol / L ] ( t = - 7.52, P ＜ 0.001 ). The decrease range of cAMP and Camp/cGMP in type A were significantly higher than that in type B(t =3.56,3.83, P ＜0.001).CONCLUSION: Effect of stress caused by college entrance examination on the content of plasma cyclic nucleotide in the type A students is significantly greater than that in the type B students.
关键词
应激,心理学/核苷酸类,环/血液/冠状动脉疾病/病因学分类
医药卫生
