中国临床康复2004，Vol.8Issue(18)：3684-3685,2.
维甲酸致大鼠骨质疏松后下颌骨骨量的变化
Variance of mandibular bone mass in rats with osteoporosis induced by retinoic acid
张军芳 1夏永祥 1曹峻岭 2毕华银2
作者信息
- 1. 南京医科大学附属南京第一医院检验科,江苏省,南京市,210006
- 2. 西安交通大学医学院地方性骨病研究所,陕西省,西安市,710061
- 折叠
摘要
Abstract
AIM: To explore the impact of osteoporosis induced by retinoic acid on bone mass of mandible in rats.METHODS: Twenty SD female rats aged three months were randomly allocated into notral group( n = 10) and model group( n = 10). Osteoporosis model was established by retinoic acid through stomach-peffusion in rats to induce mandibular bone loss. The impact of model induced by retinoic acid on mandibular bone mass was observed through the detection of bone mineral density and each serous biochemical index and the observation of the anatomic morphology of mandible as well as bone histomorphological metrological measurements, etc.RESULTS: After 15-day of the administration of retinoic acid, bone resorption regions iii subperiosteum were seen in the lower border of mandibular angle and the upper border of mandibular foramen in the rats of model group under anatomic microscope. The bone mineral density of mandibular molar part in the rats of model group was(0. 281 +0. 017) g/cm2, which was significantly lower compared with(0. 324 ±0. 005)g/cm2 of control group( t=5.944, P＜0.05).The trabecular width in model group was significantly lower than that of control group (t =26.302, P＜0.05 ). The separation of trabecular in model group was significantly higher than that of control group( t = 19. 963, P ＜ 0.05) .Compared with control group, the serous level of estradiol significantly decreased, the activity of serous alkaline phosphatase(ALP) and tartrate-resistant acid phosphatase(TRAP) was markedly increased in model group.CONCLUSION: Bone mass of mandible decreased in rats with osteoporosis induced by retinoic acid through stomach-peffusion, which indicates that this model is available and feasible in the study of mandibular bone loss.
关键词
维甲酸/大鼠/骨质疏松/下颌骨骨量/动物模型分类
医药卫生引用本文复制引用
张军芳,夏永祥,曹峻岭,毕华银..维甲酸致大鼠骨质疏松后下颌骨骨量的变化[J].中国临床康复,2004,8(18):3684-3685,2.
