中国临床康复2004，Vol.8Issue(18)：3686-3687,2.
血液透析与肾移植患者肾性骨病的转归
Comparative study of renal osteodystrophy between maintenance hemodialysis and kidney transplantation
谢飞 1王汉民 1李振江1
作者信息
- 1. 解放军第四军医大学西京医院肾内科,陕西省,西安市,710033
- 折叠
摘要
Abstract
BACKGROUND: Tile prevention and treatment of renal osteodystrophy directly affect tile long term survivals of chronic renal failure patients,thereby, there is important significances to comparative study the difference of renal osteodystrophy between maintenance hemodialysis and kidney transplantation.OBJECTIVE: To observe the variances of serous phosphorus (P) and parathyroid hormone (PTH) concentrations in the patients before and after either maintenance hemodialysis (MHD) or kidney transplantation for discussions of the treatment and prognosis of renal osteodystrophy.SETTING, PARTICIPANTS and METHODS: Forty chronic renal failure patients who accorded with the clinical diagnostic criteria and suffered from hyperphosphatemia and high serous PTH level as well were selected fiom the hemodialysis center of Xijing Hospital Affiliated to Fourth Military Medical University of Chinese PLA, in which 20 cases were allocated into MHD group and 20 cases were allocated into kidney transplantation group (transplantation group) . Another 20 healthy subjects were selected into control group. Patients in MHD group were treated with MHD, and patients il transplantation group were treated with kidney allograft transplantation with preferably postoperative recovery.MAIN OUTCOME MEASURES: The comparisons of serous P and PTH before and after treatnents in both case groups.RESULTS: The serous P and PTH after hemodialysis or kidney transplantation were significantly decreased compared with those before hemodialysis or kidney transplantation ( t = 3.15, P ＜ 0.001) . However, the serous PTH levels [(278.20+95.84) ng/L] in patients of MHD group were higher than that of control group [ (21.60 + 16.60) ng/L], moreover, the serous levels of P and PTH returned to higher levels before next MHD.CONCLUSION: Serous levels of P and PTH in patients of MHD group are still higher than that of healthy subjects, while there is no signifieant dffference of serous levels of P and PTH between the patients in kidney transplantation group and healthy subjects. Therefore, kidney transplantation is the most effective method in the treatment of renal osteodystrophy.
关键词
肾性骨营养障碍/治疗/肾性骨营养障碍/病理生理学/甲状旁腺激素类/血液/磷/血液分类
医药卫生引用本文复制引用
谢飞,王汉民,李振江..血液透析与肾移植患者肾性骨病的转归[J].中国临床康复,2004,8(18):3686-3687,2.
