中华医学杂志（英文版）2002，Vol.115Issue(1)：3-7,5.
Clinical and laboratory features of preleukemia patients
Clinical and laboratory features of preleukemia patients
摘要
Abstract
Objective To explore prospective diagnostic criteria for preleukemia.Methods A case control study was done comparing the discrepancies on clinical and laboratory features between patients with preleukemia and those with chronic aplastic anemia (CAA) or atypical paroxysmal nocturnal hemoglubinuria (a-PNH).Results There were eight variables of significance: (1) lymphocytoid micromegakaryocytes in the bone marrow; (2) immature granulocytes in the peripheral blood; (3) ≥2.0% myeloblasts in the bone marrow; (4) positive periodic acid schiff (PAS) stained nucleated erythrocytes; (5) myeloid differentiation index ≥1.8; (6) typical colonal karyotypic abnormalities; (7) negative sister chromatid differentiation; (8) cluster/colony ratio of granulocyte-macrophage colony-forming units (CFU-GM)>4.0. The following criteria were assigned: A: to meet variable one and at least two of the other seven variables and B: to meet at least four of the eight variables. All of the patients with preleukemia met either A or B and none of the patients with CAA or a-PNH did. Conclusions Preleukemia is different from CAA or a-PNH. It has its own clinical and laboratory features, which may be useful for its prospective diagnosis.关键词
preleukemia/clinical and laboratory features/diagnosisKey words
preleukemia/clinical and laboratory features/diagnosis分类
医药卫生引用本文复制引用
施均,邵宗鸿,陈桂彬,李克,刘鸿,张益枝,和虹,赵明峰,何广胜,张泓,储榆林,郝玉书..Clinical and laboratory features of preleukemia patients[J].中华医学杂志（英文版）,2002,115(1):3-7,5.基金项目
This study was supported by grants from the Chinese Academy of Medical Sciences (No. 952040) and Chinese Ministry of Health (No. 0007). （No. 952040）
