中国药理学与毒理学杂志2003，Vol.17Issue(5)：370-374,5.
乌拉坦对大鼠胰岛素水平的影响
Effect of urethane on insulin level in rats
摘要
Abstract
AIM In view of the contradictory reports in literatures, to further investigate effects of urethane on the plasma insulin levels in the fasting, glucose-loaded and the epinephrine-induced hyperglycemic rats. METHODSPlasma insulin was measured with the radio-immunoassay method. RESULTS Urethane at anesthetic dose (1.5 g*kg-1) significantly increased the plasma insulin levels at 20 min. The plasma insulin levels increased from (11±4) to (25±10) mU*L-1 (P<0.05) in fasting rats and from (11±4) to (47±6) mU*L-1 (P<0.01) in glucose-loaded rats at 50 min after administration of urethane. In hyperglycemic rats induced by epinephrine, urethane significantly increased the plasma insulin from (10±3) to (51±18) mU*L-1 at 140 min after administration of epinephrine and urethane together. In contrast with the changes in plasma insulin levels, urethane significantly increased the blood glucose levels in fasting or glucose-loaded rats at 50 min after administration of urethane, and it did not change the hyperglycemia induced by epinephrine. CONCLUSION Urethane increases the plasma insulin levels in the fasting, glucose-loaded and the epinephrine-induced hyperglycemic rats. Insulin secretion promoted by urethane may via both hyperglycemia-dependent and hyperglycemia-independent mechanisms.关键词
乌拉坦/肾上腺素/胰岛素/高血糖/大鼠Key words
urethane/epinephrine/insulin/hyperglycemia/rats分类
医药卫生引用本文复制引用
张淼,赵丁,王旻艳,任雷鸣..乌拉坦对大鼠胰岛素水平的影响[J].中国药理学与毒理学杂志,2003,17(5):370-374,5.基金项目
河北省博士后基金(1997-02) （1997-02）
