中国中西医结合杂志2001，Vol.21Issue(1)：37-39,3.
抗纤方抑制TGF-β1诱导肝细胞凋亡的实验研究
Experimental Study of Inhibitory Effect of Kangxian Recipe on TGF-β1 Induced Hepatocyte Apoptosis
摘要
Abstract
Objective: To study the inhibitory effect of Kangxian Recipe(KXR) on TGF-β1 induced hepatocyte apoptosis. Methods: The in vitro model of hepatocyte apoptosis was established by cell biologic methods, utilizing the characteristics of TGF-β1 to observe the inhibitory effect of KXR on hepatocyte apoptosis. Results: TGF-β1 induced apoptosis of hepatocyte in a dose-dependent manner. The apoptosis rate of 2.2.15 cells was 63% when 500 ng/L TGF-β1 was used, while for HepG2 cell, it was merely 44%. After treatment of 20 ng/L KXR, the apoptosis rate of the two kinds of cell lines lowered to 33% and 24% respectively. The inhibiton rate of both groups was about 50%. Conclusion: KXR had strong inhibitory effect on hepatocyte apoptosis induced by TGF-β1.关键词
抗纤方 肝细胞 凋亡 TGF-β1分类
医药卫生引用本文复制引用
张立煌,吴嘉庆,姚航平,李敏伟..抗纤方抑制TGF-β1诱导肝细胞凋亡的实验研究[J].中国中西医结合杂志,2001,21(1):37-39,3.基金项目
国家自然科学基金重点项目资助课题(No.39730420) （No.39730420）
