中国现代医学杂志2004，Vol.14Issue(4)：37-40,4.
琥珀酸对中性粒细胞的抑制作用
Succinic acid inhibits polymorphonuclear leukocyte's function
摘要
Abstract
Objective:To examine the effect of succinic acid on the function of human polymorphonuclear(PMN)leukocyte and it's special function as a virulent factor of Bacteroides Fragilis.Methods:PMN wasseperated from the blood of healthy donors,incubated with succinic acid at the concentration of 5,10,20 and 30 mmol/L for 20 min or at the concentration of 20 mmol/L for 5,10 15 and 20 min.Tested PMN's power of adherence and deoxidizing NBT.Results:Succinic acid can inhibit PMN's power of adherence and deoxidization,the inhibitory action was related to the time of incubation and succinic acid's concentration.Conclusions:Succinic acid can inhibit PMN's function and it may be an important virulent factor to Bacteroides Fragilis.关键词
琥珀酸/中性粒细胞/粘附率/硝基蓝四氮唑Key words
succinic acid/Polymorphonuclear Leukocyte/Adherence rate/NBT分类
医药卫生引用本文复制引用
任利成,黄晓元,龙剑虹..琥珀酸对中性粒细胞的抑制作用[J].中国现代医学杂志,2004,14(4):37-40,4.基金项目
Supported by National Natural Science Foundation ofChina ( No. 39970754 ) （ No. 39970754 ）
